THE IMPACT OF ANIONIC POLYMERS ON GENE DELIVERY: HOW COMPOSITION AND ASSEMBLY HELP EVADING THE TOXICITY-EFFICIENCY DILEMMA

Abstract Cationic polymers have been widely studied for non-viral gene delivery due to their ability to bind genetic material and to interact with cellular membranes.However, their charged nature carries the risk of increased cytotoxicity and interaction with serum proteins, limiting their potential in vivo application.Therefore, hydrophilic or ani

The article presents selected problems concerning custody for persons with professions of public trust.First, attention is drawn to the historical understanding of custody.In the past, custody was perceived as a manifestation of managing administration.The current way of thinking about custody results from the custody model contained in Art.17 sect